Tuesday, March 5, 2013

Increased methylation variation in epigenetic domains across cancer types.

Interesting publication quantifying epigenetic effects on tumor heterogeneity, which is one factor that makes cancer diagnosis quite difficult.  The authors of this paper looked specifically at DNA methylated regions in colon cancer cells of normal individuals vs diseased individuals.  They showed that cancer caused loss of epigenetic stability, which contributed to tumor heterogeneity.

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