Significant Genotype by Diet (G × D) Interaction Effects on Cardiometabolic Responses to a Pedigree-Wide, Dietary Challenge in Vervet Monkeys (Chlorocebus aethiops sabaeus)
My potluck paper is from the January edition of the American Journal of Primatology on a study of vervet monkeys. The study's goal was to confirm the interaction between nutrient composition of diet and genetic predispositions. They also hoped to determine whether this applies to other cardiometabolic risk factors. To test this, they changed the diet of a colony of vervet monkeys from the standard primate diet calorie allocation (18% protein, 13% fat, 69% carbohydrates) to a typical American diet calorie allocation (18% protein, 35% fat, 47% carbohydrates). Most of the cardiometabolic phenotypes (except for weight) changed adversely. Their results confirmed the interaction between nutrient composition of diet and genetic predispositions as well as the heritability of cardiometabolic phenotypes under dietary conditions. Additionally, they found that these genetic effects varied in magnitude based on the diet.
My potluck paper is from the January edition of the American Journal of Primatology on a study of vervet monkeys. The study's goal was to confirm the interaction between nutrient composition of diet and genetic predispositions. They also hoped to determine whether this applies to other cardiometabolic risk factors. To test this, they changed the diet of a colony of vervet monkeys from the standard primate diet calorie allocation (18% protein, 13% fat, 69% carbohydrates) to a typical American diet calorie allocation (18% protein, 35% fat, 47% carbohydrates). Most of the cardiometabolic phenotypes (except for weight) changed adversely. Their results confirmed the interaction between nutrient composition of diet and genetic predispositions as well as the heritability of cardiometabolic phenotypes under dietary conditions. Additionally, they found that these genetic effects varied in magnitude based on the diet.
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