A twin approach to unraveling epigenetics

This article from Trends in Genetics explores the significance of monozygotic twin studies in epigenetic research. Because MZ twins are identical in genetics, age, sex, maternal influences, and common environment, they provide a reliable, unbiased source for identifying epigenetic changes associated with complex traits. In particular, MZ twins showing disease discordance can be very helpful for disease research. The authors of this article lay out future direction and implications of twin studies in epigenetics, such as whether assisted reproductive technologies (which include IVF and can result in multiple births) affect epigenetics.