Linked below is an interesting publication regarding an
allele that is associated with greater susceptibility of suffering a disease. The concepts of this paper are (slightly)
relevant to my project this year. Here,
they are looking at existing GWAS data to gain insight into the role of
genetics on complex diseases and conditions.
What they found was that having a certain version of an allele
(generated by a single SNP in the gene FOXO3A) can cause a human to have a much
greater susceptibility to the disease. The
minor allele (“G”) is associated inflammatory diseases such as Crohns disease
and rheumatoid arthritis. On a molecular
level, minor allele carriage was shown to limit inflammatory responses by reducing
certain cytokines. Overall, variability
in prognosis is quite common in complex diseases, and this paper helps us to understand
further a the link between genotype and phenotype of a disease.
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