Sunday, November 6, 2011

Researchers discover genes involved in colorectal cancer

This study published today in Nature Genetics details the investigation of multiple networks of genes involved in driving colorectal cancer. Researchers profiled a vast number of genes related to the disease using the "Sleeping Beauty transposon system." Since APC mutations are widely believed to play a role in initiating colorectal cancer in humans, Sleeping Beauty was used to perform insertional mutagenesis in mice with Apc mutations. By identifying common insertion sites of Sleeping Beauty from a total of 446 excised tumors, hundreds of genes and 38 genetic networks were implicated as candidates for driving tumorigenesis.

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