Sunday, November 6, 2011

Genetic basis of Lupus

This Nature article found a genetic basis for systemic lupus erythematosus.  Using whole genome methylation analysis, it found hypomethylation on the IL10 and IL1R2 promoters was associated with gene  activity, resulting in misregulated activity of T and B-cells.  It also mentions several genes on the HLA region that carry risk factors for the lupus.

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