Tuesday, January 18, 2011

Yet More - epigenetics on the dad's side

New papers in Nature and Cell.

They " looked at the effect of a paternal low-protein diet in mice. Offspring of both sexes showed altered gene expression compared to controls, including genes involved in fat and cholesterol biosynthesis, consistent with physiological differences in these mice. Modest changes in DNA methylation were seen at many sites, including a reproducible change close to the Ppara gene, which encodes peroxisome proliferator-activated receptor-α, a regulator of lipid metabolism."

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