Tuesday, September 22, 2009

Wednesday, September 16, 2009

Gene therapy fixes color blindness in monkeys

HuGE Navigator


This site will be useful for looking up candidate genes: a "searchable knowledge base of genetic associations" (thanks Sameer!)

Sunday, September 13, 2009

recent positive selection on genes associated with/linked to male pattern baldness

From the paper (AGA = pattern baldness):

Interestingly, it is the AGA risk haplotype that
shows evidence for positive selection in the European
population. The AGA risk haplotype also carries a derived
non-synonymous allele (57K) in the flanking ectodysplasin
A2 receptor gene (EDA2R). The 57K allele may have been
the target of positive selection in East Asians: it shows
large allele frequency diverences between populations,
lies in a likely functional domain of the
EDA2R protein, and the ancestral allele, 57R, is conserved
from human to rat. Thus, the AGA risk haplotype may have
hitchhiked to high frequency in Europeans as a result of
positive selection on the linked 57K allele in EDA2R

Tuesday, September 8, 2009

Where Did All the Flowers Come From? Flower Genomics

Nice review of the evolution of flowering plants, and increasing complexity of their origination. Without angiosperms, no primates...?

Thursday, September 3, 2009

Recent de novo origin of human protein-coding genes

. . . human-specific protein-coding genes originating from ancestrally noncoding sequences.

interesting.

Fossil feather coloration

Yale researchers identify melanosomes in a fossil feather. Color is difficult to establish, but provides evidence of pigmentation that was previously just artistic license.

http://www.nature.com/nature/journal/v461/n7260/full/461014c.html