Toiletries to aid your microbiome!

From the New York Times Magazine:  "My No-Soap, No-Shampoo, Bacteria-Rich Hygiene Experiment"

The thousands of bacterial species that make up our microbiome provide a "second genome" with an important role in maintaining and promoting human health.  Soaps that kill bacteria on our skin might  in fact be more damaging than hygienic. Arguing that adding specific microbes can promote hygiene and treat skin ailments, a new start-up company, AOBiome, is marketing a body spray (AO+ Refreshing Cosmetic Mist) with ammonia-oxidizing bacteria.   Journalist Julia Scott tried it for a month... and seems unconvinced.

Aotus monogamy

Observations suggest that Azara's Owl Monkey is monogamous, which is rare in the animal kingdom.  they are the first primate to be documented as being monogamous.
**Note: I saw this blurb in the NY Times Science Times a few weeks back and forgot to post it--sorry for the delay!  The NY times blurb and the original paper are linked here:
http://www.nytimes.com/2014/03/25/science/no-monkeying-around-for-these-partners.html?_r=0
http://rspb.royalsocietypublishing.org/content/281/1782/20140195

Correlated evolution of sensory structures and sensory genes in mammals

An article by Garrett & Steiper just published in Proceedings of the Royal Society B looked at anatomical correlates of main olfactory system (ethmoid) and vemoronasal system (vemoronasal organ, VNO) across mammals as well as the size of the related gene families (OR, V1R, and V2R) in mammalian genomes. They found that absolute ethmoid area is correlated with the proportion of functional ORs and that the relative size and complexity of the VNO is correlated with proportion of functional V1R genes in mammalian genomes. These results show nice concordance between anatomical and molecular evolution and may indicate a role for natural selection in the evolution of these genes families.

Genome wide association of methylation with BMI

A recent issue of The Lancet featured an epigenome wide association study (EWAS) of methylated CpGs associated with BMI. Sites were identified in an initial cohort of 479 Europeans and, after filtering data for false positives, inspected in a replication cohort of 339 people. Sites still significant were tested in a larger second replication cohort of 1789 individuals. Five sites were identified as significantly associated with BMI, three of which fall within the first intron of the gene HIF3A, which encodes a subunit of the Hypoxia Inducible Transcription Factor (HIF). Chromatin state at this intron indicates regulatory activity. For all these cases, increasing methylation is linearly correlated with increasing BMI. Notably, the association is tissue specific, manifesting in blood and adipose tissues, but not skin.

Alu elements found to function similarly to enhancers

In a recent issue of Cell authors Su et al. carried out genome-wide analyses of genomic distribution, evolutionary conservation, histone positioning and epigenetic profiles to examine the characteristics of Alu elements. They found that Alu elements in multiple tissues and cell-lines resemble those of putative transcription enhancers. They also find that Alus show long-range interactions with gene promoters, and their similarity to enhancers becomes more prominent with their age in the human genome. The authors conclude that some Alu elements can function as enhancers, and, further, that many more Alus may be proto-enhancers that serve as a repertoire for the de novo birth of enhancers.

A critical period discovered in development of the olfactory bulb

Authors Tsai and Barnea report in the most recent issue of Science that a critical period exists during which an olfactory “sensory map” becomes established. Previous findings show that the olfactory system exhibits enhanced plasticity that is maintained throughout life due to continuous neurogenesis of sensory neurons in the nose and olfactory bulb. However, the authors found evidence in mice that there is less plasticity than originally thought and that a sensory map is created during a developmental critical period. Specifically, the authors were able to test the neural pathways of transgenic mice, finding that perinatal expression of the transgenic odorant receptor (i.e. before the sensory map is established) led to activation of new axons. In contrast, expression of the transgenic receptor after the sensory map was established did not activate new axons.

A review of methods for DNA methylation analysis

Peter Laird, in a 2010 issue of Nat. Rev. Genet., reviews the technology of genome-wide DNA methylation analysis. The review gives the pros and cons of each methodology, as well as the principle behind the analyses. Additionally, he provides information on statistical issues and a list of bioinformatics resources for DNA methylation analysis.